Spend two days visiting Ephesus and Pamukkale on a tour from Istanbul that travels round-trip by overnight bus. See the ancient ruins of Ephesus, Temple of Artemis, House of Virgin Mary, and Isa Bey Mosque in one day, then visit Pammukale and Hierapolis the following day. Your tour includes hotel pickup and drop-off at each location, two days of guided tours, overnight accommodation near Ephesus, and three meals.